TriGene Advance Disinfectant

Description

Micro-emulsion particles carry disinfectant molecules through cell walls

At the heart of the all-new TriGene Advance formula are the micro-emulsion particles (Nano particles) that enable the active ingredient molecules in the product to be carried rapidly through cell walls of micro-organisms.

Rapid penetration of cell walls by the powerful TriGene Advance disinfectant constituents ensures cell death is equally rapid. TriGene Advance works up to 70% quicker than conventional high level disinfectants and achieves apoptosis (cell death) rather than merely suspending activity as with conventional disinfectant products.

Micro-emulsion particles can enter microscopic surface fissures

Because the Nano Particles can enter areas like microscopic fissures and crevices in hard surfaces, which have not hitherto been penetrable by conventional carrier systems, disinfectant actives are able to spread across a complete surface area, to perform a far more thorough anti pathogenic cleansing task than was previously possible.

The synergistic blend of TriGene Advance active ingredients produces the fastest acting and most efficient anti viral and sporicidal agent presently available in non-oxidising disinfectant technology.

A safer to use disinfectant all round

Health and safety issues and product compatibility are of real importance to everyone. EA International encourages all users of chemical products to pay special attention to the advisory statements within Material Safety Data Sheets and on product labelling.

Lower levels of actives and safety of nano particles

TriGene Advance is able to rely on lower levels of active ingredients than previously used, due to the formulation’s revolutionary method of delivering diluted disinfectant to the cells of micro-organisms. The simple prokaryotic cellular structure of micro-organisms provides little resistance to the active ingredients of TriGene Advance but the hugely more complex eukaryotic structure of the mammalian cell membrane means TriGene Advance is not cyto-toxic to mammalian tissue. Using the new system in the presence of human and animal skin is therefore of low risk. Notwithstanding this, instructions should always be followed carefully and gloves worn where advised.

Material compatibility

Independent laboratory testing demonstrates no corrosion or deterioration of the following materials, even after long-term repeated immersions: Rubber compounds, Plastics, Fibreglass, Stainless Steel, Mild Steel, Aluminium, Copper, Brass and other materials found in clinical practice, in particular synthetic floors, instruments and devices.

Material safety data sheet extracts (concentrate)

Exposure controls

Skin contact: Low risk – may degrease skin leading to dryness if excessive contact.
Eye contact: Low risk – may cause temporary discomfort.
Inhalation: Low risk – avoid inhalation of fine mist spray.
Inhalation (long term): Low risk – avoid inhalation of fine mist spray.
Ingestion: Low risk – substantial ingestion will cause discomfort to mouth and digestive tissues.

Physical and chemical properties

pH: 5.5 (approx)

Toxicological information

Human Studies: 4 hour and 20 hours patch tests have shown minor skin reddening but no harmful effects.

Transport information

No special conditions apply. Not dangerous.

Accidental release measures

Environmental precautions: Product is biodegradable under OECD conditions operational 6/1995.
Clean up method: Flush to drain with copious water or soak up onto inert material.

Ecological information

No known adverse effects from normal use.
The TriGene Advance formula fully meets the criteria of the European Biocides Regulations which came into force in 2007.
TriGene Advance has not been tested on animals to secure its supporting data.

Microbiological economy of use

Because required results are generated with higher dilutions of TriGene Advance , greater economies are effected at point of use. For example, an acceptable ‘kill’ rate for Parvo virus is widely accepted as 99.99% (log 4) in a thirty minute exposure. This corresponds to the test protocol used by the UK Animal Health Institute and to the protocol accepted world-wide under EPA conditions.

TriGene Advance produces a 99.999+% (log 5+) kill rate in Parvo under the EPA protocol at a dilution of 1:100 (1 part disinfectant in 100 parts water).

True broad spectrum activity

Users of disinfectants in human health/laboratory and life science environments require maximum protection from the use of a disinfectant with proven independent microbiological test certification. Many disinfectants require strong dilutions for critical risk areas like Parvovirus or TB, yet are marketed for use at much weaker dilutions for “broad spectrum activity”, putting both the organisation and patients at risk of cross infection.

TriGene Advance users can rely on one dilution (1:100) for broad spectrum activity (supported by independent testing) in high risk conditions against viruses, mycobacteria, fungi and bacterial organisms and another for economic general purpose disinfection (1:200) in intermediate risk areas.

Worktops/equipment

Wash down all surfaces with TriGene Advance at 1:100 and dry with paper towel or allow to dry naturally. Alternatively use TriGene Advance in RTU (ready to use) trigger spray and wipe excess moisture with paper towel and allow to dry.
TriGene Advance wipes can also be used to wipe surfaces.

Device immersion

Non-critical devices can be soaked in TriGene Advance if required during a period of high risk in a solution of 1:100 for 20 mins.
Fabrics can be soaked in a solution of TriGene Advance at 1:100 for 10 minute. They can also be washed in an automatic washing machine using 50ml per 4kg load during a normal washing cycle.

Floor, walls

For general washing of floors and surfaces use TriGene Advance at 1:200. Use with mop and bucket on floors, remove excess moisture and allow to dry.
Wash other surfaces, rince where necessary and remove excess moisture and allow to dry.

Fogging and pressure washing

Where applicable TriGene Advance can be used in pressure washing machines at a dilution of 1:200, rinsed and allowed to dry.
Where aerial fogging is required, non-fragranced product should be used at a dilution of 1:200. masks should be worn and the area vacated until dry.

Wipes

TriGene Advance wipes, impregnated at 1:10 are recommended for disinfection of probes, transducers, incubators and for machines used for x-ray, mammography, radiology, etc.
As well as other sealed medical devices.

A Selection of Efficacy Test Results Held on File

Methodology	Organism	Log Reduction	Laboratory	Dilution	Clean/dirty conditions or low level soiling/high level soiling	Time
Mycobactericidal
P2, S1 EN 14348	Mycobacterium avium	>2.79	Abbott Analytical	1:100	dirty	30 mins
	Mycobacterium bovis	1.39	Abbott Analytical	1:100	dirty	30 mins
	Mycobacterium fortuitum	<7.14	Abbott Analytical	1:100	dirty	30 mins
	Mycobacterium terrae (TB)	>5.79	Abbott Analytical	1:100	dirty	30 mins
Virucidal
P2, S1 EN 14476	Canine parvovirus	5.67	Blutest	1:100	clean	30 mins
	Adenovirus T5	4.16	Blutest	1:100	clean	30 mins
	Feline Calicivirus	5.50	Blutest	1:100	clean	30 mins
U.S. EPA	Adenovirus T5	>5	ATS	1:100	5% FBS	30 mins
	Hepatitis B	>4.21	ATS	1:100	N/A	30 mins
	Human Immunodeficiency Virus T1	>4.5	ATS	1:100	5% FBS	30 mins
	Human Coronavirus	>4.75	ATS	1:100	1% FBS	30 mins
Fungicidal / Yeasticidal
P2, S2 EN 13697	Candida albicans	>3.4	MGS	1:100	dirty	5 mins
P2, S1 EN 13624	Candida albicans	>5.06	MGS	1:100	clean	5 mins
Bactericidal
P2,S2 EN 14561	Enterococcus hirae	5.24	MGS	1:100	clean	5 mins
P2, S1 EN 1656	Enterococcus hirae	>5.08	MGS	1:200	low level soiling	5 mins
	Staphylococcus aureus	>5.12	MGS	1:200	low level soiling	5 mins
	Campylobacter jejuni	>5.36	MGS	1:200	low level soiling	5 mins
	Stenotrophomonas maltophilia	>5.53	MGS	1:200	low level soiling	5 mins
	Methicillin-resistant Staphylococcus pseudimintermedius	>5.44	MGS	1:200	low level soiling	5 mins
	Proteus vulgaris	>5.16	MGS	1:200	low level soiling	5 mins
	Streptococcus equi	>5.34	MGS	1:200	low level soiling	5 mins
	Rhodococcus equi	5.40	MGS	1:100	low level soiling	5 mins
	Bordatella bronchiseptica	4.15	MGS	1:100	low level soiling	5 mins
P2, S1 EN 13727	Methicillin-resistant Staphylococcus aureus	>5.34	MGS	1:200	clean	5 mins
	Enterococcus hirae	>5.0	Eclipse	1:200	clean and dirty	5 mins
	Staphylococcus aureus	>5.0	Eclipse	1:200	clean and dirty	5 mins
	Pseudomonas aeruginosa	>5.0	Eclipse	1:200	clean and dirty	5 mins
P2, S1 EN 1276	Enterococcus hirae	>5.0	Eclipse	1:200	clean and dirty	5 mins
	Staphylococcus aureus	>5.0	Eclipse	1:200	clean and dirty	5 mins
	Pseudomonas aeruginosa	>5.0	Eclipse	1:200	clean and dirty	5 mins
	Escherichia coli	>5.0	Eclipse	1:200	clean and dirty	5 mins
P2, S1 EN 1650	Microsporum audouinii	>4.3	University of Huddersfield	1:100	clean	30 mins
	Trichophyton tonsurans	>4.1	University of Huddersfield	1:100	clean	60 mins

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